About the Study
Acanthamoeba corneal infections are challenging to treat. Patients often need eyedrops for the infection for 6 to 12 months or even longer. Doctors donʼt know the best way to treat acanthamoeba. Some doctors think steroid drops help with vision and pain, but other doctors think steroids prolong the infection.
In this study, everyone will be treated with an eyedrop for acanthamoeba for the duration of the infection. After 1 month, some people will be started on steroid eyedrops and other people will get lubricating eyedrops. We will follow everyone closely to see if steroids are safe and effective for acanthamoeba infections
What is involved? You will be treated with an eyedrop for acanthamoeba for 1 month. After 1 month, if you are still eligible, you will be “randomized” to get either the steroid eyedrop or a lubricating eyedrop. (Randomization is similar to flipping a coin.) You will not know which treatment you get. You will take the study eyedrop for 2 months while you are still taking the anti-amoebic eyedrop. You will have follow-up visits at the 1-month visit, and also at 6 weeks, 2 months, 3 months, 6 months, and 12 months. (You will also have other visits for your clinical care as recommended by your doctor.) You can expect each visit to last about 2 hours. You will have several different types of eye images taken throughout the study, as well as a very precise test of your vision. For more information, contact your closest enrollment center.
Enrollment Centers
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If you are a referring doctor, please see the Doctor Information here.